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Ascozin Tablets

Ascozin Tablets

Why you have been prescribed this medicine?

You have been prescribed this medicine if you have any of the following:

When you should consult your doctor?

You should consult your doctor if you experience any of the following:
Usually the preparation is well tolerated. During a long-term usage of high doses there can be possible follow side effects:

GIT:
nausea, vomiting, heartburn, diarrhea.

CNS:
hyperexcitability of CNS, headache.

Urinary system:
formation of urinary, cystine and oxalate concernments.
Skin and subcutaneous tissue: allergic reactions.

Blood system:
It can cause erythrocyte hemolysis in patients with insufficiency of glucose-6-phosphatdehydrogenase of hematocytes.

What to do if you miss a dose?

If it is almost time for your next dose, skip the dose you missed and take your next dose when you are meant to. Otherwise take it as soon as you remember and then go back to taking it as you would normally.

Things you MUST NOT DO while on this medicine?

Ascozin® increases salicylates (increases a risk of crystalluria), ethynilestradiol, benzylpenicillin and tetracyclines concentrations in blood, and decreases per oral contraceptives concentration in blood. It reduces anticoagulation effect of coumarin derivatives. It improves iron drugs absorption in intestine. It increases general clearance of ethyl alcohol. Quinolone drugs, calcium chloride, salicylate, corticosteroid decrease vitamin C reserve when used for a long term. Corticosteroids (cortisone and prednisolone), which are administered in concrete diseases (arthritis, bronchial astma etc), also reduce vitamin C and zinc levels.
Concurrent usage of ascorbic acid and deferoxamine enhances tissue toxicity of iron, especially in cardiac muscle that can cause decompensation of blood circulatory system. It can be used only in 2 hours after deferoxamine injection. A long-term administration of high doses in patients, who are treated by disulfiram, inhibits disulfamide-alcohol reaction.
High doses of the preparation decrease efficacy of tricyclic depressants.

What to do if you accidentally take too much (overdose) of the medicine?

Symptoms:
nausea, vomiting, intestine spasm, diarrhea; it is possible allergic reaction, kidney dysfunction, blood pressure increase, hyperexcitability of CNS, sleep disturbance.

Treatment:
It is symptomatic.

Is it safe in pregnancy and breast-feeding?

Tell your doctor immediately if you become pregnant while taking this medication. For safety of any drug during pregnancy or breastfeeding – please consult your doctor.

Storage Conditions:

Store in a dry, protected from light place at a temperature not more than 25° C.
Keep it out of reach of children.

Drug Description

COMPOSITION:
Each chewable tablet contains:
Ascorbic acid USP 100 mg
Sodium ascorbate USP 450 mg equivalent to Ascorbic acid 400 mg
Zinc oxide BP equivalent to Zinc 15 mg

Indications and dosage.

INDICATIONS:
Deficiency and increased requirement of vitamin C. Deficiency and increased requirement of Zinc.

DOSAGE:
Adults and adolescents:
1 chewable tablet daily.
The recommended daily dose of one tablet per day must not be exceeded.

Side effects and drug interactions.

ADVERSE REACTIONS:
The most commonly found adverse reactions are mild transient multivitamin/mineral
gastrointestinal disturbances, occurring in up to 5% of patients.
Allergic reactions are very rare (<1/10,000). Urticaria,
throat swelling and rash have been reported in isolated cases. Ascorbic acid
may cause haemolytic anaemia in certain individuals with a deficiency in glucose-6-
phosphatedehydrogenase. GIT:
nausea, vomiting, heartburn, diarrhea.

CNS:
hyperexcitability of CNS, headache.

Urinary system:
formation of urinary, cystine and oxalate concernments.

Skin and subcutaneous tissue:
allergic reactions.

Blood system:
It can cause erythrocyte hemolysis in patients with insufficiency of glucose-6-phosphatdehydrogenase of hematocytes.

INTERACTIONS WITH OTHER MEDICAMENTS: Vitamin C (ascorbic acid) may interfere with some tests for glucose in the urine. Therefore, the administration of ascorbic acid (vitamin C) should be interrupted several days before such tests are performed

Warnings and precautions

Pregnancy and lactation:
No indications exist that the nutrients contained in Ascozin chewable tablets have any adverse effects on pregnancy or on the health of the foetus/newborn child at the recommended dose of one tablet per day. However, Ascozin chewable tablets should be administered in pregnancy only when clinically indicated. The vitamins and minerals in Ascozin chewable tablets are excreted into breast milk, but harmful effects on the child are unlikely at therapeutic doses.
Children:
Ascozin® is not administered to children.

PRECAUTIONS:
The recommended daily dose of one tablet per day must not be exceeded. It should only be used for the treatment of vitamin C deficiency if the cause is dietary. Patients receiving any other medication or those under medical care should consult a physician before taking this medicinal product. Patients with rare hereditary problems of galactose intolerance, the Lapp lactase deficiency or glucose-galactose malabsorption should not take Ascozin Chewable Tablets.

Overdosage and Contraindications

Overdose:
Symptoms:
nausea, vomiting, intestine spasm, diarrhea;
it is possible allergic reaction, kidney dysfunction, blood pressure increase, hyperexcitability of CNS, sleep disturbance.

Treatment:
It is symptomatic.
> CONTRAINDICATIONS:
Known allergy or hypersensitivity to the active substances or to any of the excipients in Ascozin
chewable tablets.
Hypercalcemia
Hypermagnesemia
Nephrolithiasis/urolithiasis
Hemochromatosis
Ascorbic acid should not be given to patients with hyperoxaluria, reduced renal function or
deficiency of glucose-6-phosphate dehydrogenase

Clinical pharmacology.

PHARMACODYNAMIC PROPERTIES:
Pharmacotherapeutic group: Vitamin C and zinc

ATC code:
A 11 E C
The vitamin content of the Ascozin chewable tablets is intended for use in deficiencies and increased requirement states. As a result, the content of the ascorbic acid and zinc in Ascozin chewable tablets was formulated above the recommended nutritional Recommended Dietary Allowances (RDAs) which are not: intended for therapeutic use. Each tablet contains: ascorbic acid 500 mg (RDA = 60 mg). Since the water-soluble vitamins are not stored by the body to any appreciable extent, the supply of water-soluble vitamins might be insufficient in the elderly, during pregnancy and lactation, in persons on diet, during certain chronic diseases, during extensive physical exercise and during long-lasting stress and chronic alcohol abuse. The demand of vitamin C (ascorbic acid) is higher than normal in smokers and in women using oral contraceptive. Vitamin C (ascorbic acid) is a biological antioxidant and plays an important role in the inactivation of free radicals. It is also required for the activity of a number of enzymes involved in hydroxylation reactions and in the metabolism of e.g. cholesterol, bile acids and drugs. Vitamin C (ascorbic acid) enhances the absorption of iron in the intestine, influences folic acid metabolism and leukocyte function. It promotes the formation of connective tissue and is essential for the formulation and function of teeth, bones and capillaries. Zinc is an important trace element in the body and is involved as a catalyst in more than 200 enzymes. It is a natural constituent of many proteins, hormones, neuropeptides and hormone receptors. Amongst others, zinc is directly involved in the synthesis of co-enzymes derived from vitamin B6 (pyridoxine). PHARMACOKINETIC PROPERTIES: Human health and well-being is naturally dependent on the continuous uptake and management of vitamins and trace elements, and their absorption, distribution, metabolism and elimination are maintained by specific physiological mechanisms. As the Bayer Multivitamin & Mineral Film Coated Tablets are completely dissolved in the gastrointestinal tract a good availability of these compounds is assured..

Shelf-life:
2 years.

Storage:
Store below 30ºC. Store in cool and dry place.

Package:
Tablets Aluminium strip of 10 tablets. 1, 3 or 10 strips are packed in a carton.
There are 10 tablets in a strip, there are 10 strips are in a carton box No. 100 (10 x 10).

Conditions of supply:
Without prescription.

CERTIFICATES

KEEP IN TOUCH

Kusum Healthcare
D-158A, OKHLA,INDUSTRIAL AREA,
PHASE-I, NEW DELHI,
Pin 110020
INDIA
Tel: 011-41005147, 011-40514919
Fax: +91-11-40527575